Epigenetic Chemical Probes

Use of small molecules as potential chemical probes to explore biological systems involves interactions with a wide range of proteins. Proteins such as the bromodomain and extra-terminal domain (BET) protein family consisting of BRD2, BRD3, BRD4, are found to be epigenetic readers and key targets for cancer (multiple myeloma, acute myeloid leukemia, midline carcinoma) and other diseases like Alzheimer’s, asthma and COPD, Atherosclerosis, Diabetes and Schizophrenia.

ChemRoutes based on partners inputs, designs compounds that bind to targets with chemical probe features such as good toxicity profiles, in vitro potency and higher and differing selectivity.