Chemical biology has helped develop new and novel drug targets. These targets have expanded G protein coupled receptors and kinase based research. They have provided new protein-protein targets. Small organic molecules also affect and modulate human behaviour. To understand the chemistry of a biological system as it relates to health or disease, chemistry has to be considered in context of the whole organism. Structure and biological activity have shown a reciprocal relationship that informs molecular design for a biological goal.
Protein-protein interactions are considered one of the most difficult target classes to inhibit with small molecules, yet they also represent a large and important class for therapeutic intervention. In collaboration with our partners we are in the process of using nanotechnology-based assays to design and test protein-protein interactions at the single molecule level in the area of infectious diseases, neurodegenerative diseases and prion based diseases.